<i>Blautia producta</i> displays potential probiotic properties against dextran sulfate sodium-induced colitis in mice

Blautia has attracted attention because of its potential efficacy in ameliorating host energy metabolism and inflammation. This study aims to investigate the influences producta D4 on colitis induced by dextran sulfate sodium (DSS) reveal underlying mechanisms. Results showed that B. producta intervention significantly relieved body weight loss, suppressed elevation pro-inflammatory cytokines [including interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β)] excessive oxidative stress [myeloperoxidease (MPO) activity, superoxide dismutase (SOD) glutathione peroxidase (GSH-Px) malondialdehyde (MDA) level] mice. Moreover, concentrations tight junction proteins (occludin, claudin-1, ZO-1) related intestinal barrier were obviously elevated, colitis-related TLR4/NF-κB pathway activation was remarkably inhibited after intervention. The microbial disorder evidently ameliorated increasing relative abundance Clostridium sensu stricto 1, Bifidobacterium, GCA-900066225, Enterorhabdus, reducing Lachnospiraceae NK4A136 group. In conclusion, oral administration could ameliorate DSS-induced suppressing inflammatory responses, maintaining barrier, inhibiting TLR4/ NF-κB pathway, regulating microbiota balance. These results are conducive accelerate development as a functional probiotic for colitis.